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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMAD1
All Species:
23.94
Human Site:
T222
Identified Species:
52.67
UniProt:
Q15797
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15797
NP_001003688.1
465
52260
T222
P
F
Q
M
P
A
D
T
P
P
P
A
Y
L
P
Chimpanzee
Pan troglodytes
XP_001148109
465
52214
T222
P
F
Q
M
P
A
D
T
P
P
P
A
Y
L
P
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532681
465
52174
T222
P
F
Q
M
P
A
D
T
P
P
P
A
Y
L
P
Cat
Felis silvestris
Mouse
Mus musculus
P70340
465
52100
T222
P
F
Q
M
P
A
D
T
P
P
P
A
Y
L
P
Rat
Rattus norvegicus
P97588
468
52695
P225
M
P
A
D
T
P
P
P
A
Y
L
P
P
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510186
465
52277
T222
P
F
Q
M
P
A
D
T
P
P
P
A
Y
L
P
Chicken
Gallus gallus
Q56I99
465
52210
P222
F
Q
L
P
A
D
T
P
P
P
A
Y
M
P
P
Frog
Xenopus laevis
NP_001079973
464
52355
T221
P
F
Q
I
P
A
D
T
P
P
P
A
Y
M
P
Zebra Danio
Brachydanio rerio
Q9I8V2
472
53048
P229
P
F
Q
M
P
E
T
P
P
P
A
Y
M
P
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42003
455
50486
S212
S
V
N
S
N
P
N
S
P
Y
D
S
L
A
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q02330
418
47907
Q182
N
V
N
F
T
A
N
Q
F
H
Q
Y
N
P
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
N.A.
99.3
N.A.
98.7
97.4
N.A.
98.9
90.3
95.6
88.5
N.A.
75
N.A.
51.6
N.A.
Protein Similarity:
100
100
N.A.
99.5
N.A.
99.3
97.8
N.A.
99.3
92.4
97.4
93.8
N.A.
83.6
N.A.
63.8
N.A.
P-Site Identity:
100
100
N.A.
100
N.A.
100
0
N.A.
100
20
86.6
53.3
N.A.
6.6
N.A.
6.6
N.A.
P-Site Similarity:
100
100
N.A.
100
N.A.
100
0
N.A.
100
20
100
53.3
N.A.
26.6
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
10
64
0
0
10
0
19
55
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
0
10
55
0
0
0
10
0
0
0
10
% D
% Glu:
0
0
0
0
0
10
0
0
0
0
0
0
0
10
0
% E
% Phe:
10
64
0
10
0
0
0
0
10
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% G
% His:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% H
% Ile:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
10
0
0
0
0
0
0
0
10
0
10
46
0
% L
% Met:
10
0
0
55
0
0
0
0
0
0
0
0
19
10
0
% M
% Asn:
10
0
19
0
10
0
19
0
0
0
0
0
10
0
10
% N
% Pro:
64
10
0
10
64
19
10
28
82
73
55
10
10
28
73
% P
% Gln:
0
10
64
0
0
0
0
10
0
0
10
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
10
0
0
10
0
0
0
10
0
0
0
10
0
0
0
% S
% Thr:
0
0
0
0
19
0
19
55
0
0
0
0
0
0
0
% T
% Val:
0
19
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
19
0
28
55
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _